Function and Biology

HUMAN ARYLSULFATASE A

Source organism: Homo sapiens
Biochemical function: arylsulfatase activity
Biological process: post-translational protein modification
Cellular component: extracellular exosome

EC 3.1.6.8: Cerebroside-sulfatase

Reaction catalysed:
A cerebroside 3-sulfate + H(2)O = a cerebroside + sulfate.
Comments:
  • Hydrolyzes galactose-3-sulfate residues in a number of lipids.
  • Also hydrolyzes ascorbate 2-sulfate and many phenol sulfates.
Systematic name:
Cerebroside-3-sulfate 3-sulfohydrolase
Alternative Name(s):
  • Arylsulfatase A
  • Cerebroside sulfate sulfatase

Sequence families

Pfam Protein families (Pfam)
PF00884
Domain description: Sulfatase
Occurring in:
  1. Arylsulfatase A
1 copy of Pfam domain PF00884 (Sulfatase) in Arylsulfatase A in PDB 1auk.

PF14707
Domain description: C-terminal region of aryl-sulfatase
Occurring in:
  1. Arylsulfatase A
1 copy of Pfam domain PF14707 (C-terminal region of aryl-sulfatase) in Arylsulfatase A in PDB 1auk.

InterPro InterPro annotations
IPR000917
Domain description: Sulfatase, N-terminal
Occurring in:
  1. Arylsulfatase A
IPR017849
Domain description: Alkaline phosphatase-like, alpha/beta/alpha
Occurring in:
  1. Arylsulfatase A
IPR017850
Domain description: Alkaline-phosphatase-like, core domain superfamily
Occurring in:
  1. Arylsulfatase A
IPR024607
Domain description: Sulfatase, conserved site
Occurring in:
  1. Arylsulfatase A

Structure domains

CATH CATH domains
3.40.720.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Alkaline Phosphatase, subunit A
Homology: Alkaline Phosphatase, subunit A
Occurring in:
  1. Arylsulfatase A
1 copy of CATH domain 3.40.720.10 (Alkaline Phosphatase, subunit A) in Arylsulfatase A in PDB 1auk.
3.30.1120.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Arylsulfatase, C-terminal domain
Homology: Arylsulfatase, C-terminal domain
Occurring in:
  1. Arylsulfatase A
1 copy of CATH domain 3.30.1120.10 (Arylsulfatase, C-terminal domain) in Arylsulfatase A in PDB 1auk.
SCOP SCOP annotation
53653
Class: Alpha and beta proteins (a/b)
Fold: Alkaline phosphatase-like
Superfamily: Alkaline phosphatase-like
Occurring in:
  1. Arylsulfatase A
1 copy of SCOP domain 53653 (Arylsulfatase) in Arylsulfatase A in PDB 1auk.