PDBe 1aui

X-ray diffraction
2.1Å resolution

HUMAN CALCINEURIN HETERODIMER

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Chain: A
Molecule details ›
Chain: A
Length: 521 amino acids
Theoretical weight: 58.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q08209 (Residues: 1-521; Coverage: null%)
Gene names: CALNA, CNA, PPP3CA
Sequence domains: Calcineurin-like phosphoesterase
Structure domains: Purple Acid Phosphatase; chain A, domain 2
Calcineurin subunit B type 1 Chain: B
Molecule details ›
Chain: B
Length: 169 amino acids
Theoretical weight: 19.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63098 (Residues: 2-170; Coverage: null%)
Gene names: CNA2, CNB, PPP3R1
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P212121
Unit cell:
a: 48.81Å b: 104.34Å c: 177.77Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.187 not available
Expression system: Escherichia coli