Function and Biology

CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PYRROLIDINONE INHIBITOR

Source organism: Homo sapiens
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis
Cellular component: not assigned

EC 3.4.22.38: Cathepsin K

Reaction catalysed:
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
Systematic name:
-
Alternative Name(s):
  • Cathepsin O
  • Cathepsin O2
  • Cathepsin X

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00112
Domain description: Papain family cysteine protease
Occurring in:
  1. Cathepsin K
The deposited structure of PDB entry 1au4 contains 1 copy of Pfam domain PF00112 (Papain family cysteine protease) in Cathepsin K. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000668
Domain description: Peptidase C1A, papain C-terminal
Occurring in:
  1. Cathepsin K
IPR025661
Domain description: Cysteine peptidase, asparagine active site
Occurring in:
  1. Cathepsin K
IPR025660
Domain description: Cysteine peptidase, histidine active site
Occurring in:
  1. Cathepsin K
IPR000169
Domain description: Cysteine peptidase, cysteine active site
Occurring in:
  1. Cathepsin K
IPR013128
Domain description: Peptidase C1A
Occurring in:
  1. Cathepsin K
IPR039417
Domain description: Papain-like cysteine endopeptidase
Occurring in:
  1. Cathepsin K
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Cathepsin K

Structure domain

CATH CATH domain
3.90.70.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Cathepsin B; Chain A
Homology: Cysteine proteinases
Occurring in:
  1. Cathepsin K
The deposited structure of PDB entry 1au4 contains 1 copy of CATH domain 3.90.70.10 (Cathepsin B; Chain A) in Cathepsin K. Showing 1 copy in chain A.
SCOP SCOP annotation
54002
Class: Alpha and beta proteins (a+b)
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Occurring in:
  1. Cathepsin K
The deposited structure of PDB entry 1au4 contains 1 copy of SCOP domain 54002 (Papain-like) in Cathepsin K. Showing 1 copy in chain A.