› 1au1

X-ray diffraction
2.2Å resolution

HUMAN INTERFERON-BETA CRYSTAL STRUCTURE

Released:
DOI: 10.2210/pdb1au1/pdb
PDB entry 1au1 coloured by chain, front view.
PDB entry 1au1 coloured by chain, side view.
PDB entry 1au1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human interferon beta at 2.2-A resolution.
Karpusas M, Nolte M, Benton CB, Meier W, Lipscomb WN, Goelz S
Proc Natl Acad Sci U S A 94 11813-8 (1997)
PMID: 9342320

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134397 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Interferon beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 166 amino acids
Theoretical weight: 20.05 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01574 (Residues: 22-187; Coverage: 100%)
Gene names: IFB, IFNB, IFNB1
Sequence domains: Interferon alpha/beta domain
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, G6D
Carbohydrate polymer
Carbohydrate polymer : NEW Components: BGC, G6D
Carbohydrate polymer
1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P212121
Unit cell:
a: 55.3Å b: 65.9Å c: 121.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.223 0.283
Expression system: Cricetulus griseus

Quick links

Citations

28 review citations

Interferons, interferon-like cytokines, and their receptors.
Pestka et al. (2004)
27 more

39 mentions without citation

Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation.
Piehler et al. (2012)
38 more