Structure analysis

HLA-DR1 (DRA, DRB1 0101) HUMAN CLASS II HISTOCOMPATIBILITY PROTEIN (EXTRACELLULAR DOMAIN) COMPLEXED WITH ENDOGENOUS PEPTIDE

X-ray diffraction
2.45Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer

Binding statistics and energies are not available for this assembly
Assembly 2
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Multimeric state: hetero trimer
Accessible surface area: 17400 Å2
Buried surface area: 7400 Å2
Dissociation area: 1,300 Å2
Dissociation energy (ΔGdiss): 15 kcal/mol
Dissociation entropy (TΔSdiss): 9 kcal/mol
Interface energy (ΔGint): -37 kcal/mol
Symmetry number: 1
Assembly 3
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Multimeric state: hetero trimer

Binding statistics and energies are not available for this assembly
Assembly 4
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Multimeric state: hetero trimer

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: C, F, I, L
Length: 15 amino acids
Theoretical weight: 1.86 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01892 (Residues: 127-141; Coverage: 4%)
Gene names: HLA-A, HLAA

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