PDBe 1aqd

X-ray diffraction
2.45Å resolution

HLA-DR1 (DRA, DRB1 0101) HUMAN CLASS II HISTOCOMPATIBILITY PROTEIN (EXTRACELLULAR DOMAIN) COMPLEXED WITH ENDOGENOUS PEPTIDE

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A-2 alpha chain Chains: C, F, I, L
Molecule details ›
Chains: C, F, I, L
Length: 15 amino acids
Theoretical weight: 1.86 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01892 (Residues: 127-141; Coverage: 4%)
Gene names: HLA-A, HLAA
HLA class II histocompatibility antigen, DR alpha chain Chains: A, D, G, J
Molecule details ›
Chains: A, D, G, J
Length: 192 amino acids
Theoretical weight: 22.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01903 (Residues: 26-217; Coverage: 84%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DRB1-1 beta chain Chains: B, E, H, K
Molecule details ›
Chains: B, E, H, K
Length: 198 amino acids
Theoretical weight: 22.96 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04229 (Residues: 30-227; Coverage: 84%)
Gene name: HLA-DRB1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: C2
Unit cell:
a: 134.514Å b: 134.32Å c: 131.232Å
α: 90° β: 104.82° γ: 90°
R-values:
R R work R free
0.216 0.216 0.279
Expression systems:
  • Not provided
  • Spodoptera frugiperda