› › Structure analysis

COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201

X-ray diffraction
2.6Å resolution
PDB entry 1ao7 coloured by chain, front view.
PDB entry 1ao7 coloured by chain, side view.
PDB entry 1ao7 coloured by chain, top view.
Source organisms:
Assemblies composition:
hetero pentamer (preferred)
hetero decamer
Entry contents: 5 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero pentamer
Accessible surface area: 33490.32 Å2
Buried surface area: 8464.65 Å2
Dissociation area: 1,264 Å2
Dissociation energy (ΔGdiss): 2.44 kcal/mol
Dissociation entropy (TΔSdiss): 12.32 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-100460
Assembly 2
Download    3D Visualisation
Multimeric state: hetero decamer
Accessible surface area: 67944.59 Å2
Buried surface area: 15968.69 Å2
Dissociation area: 7,664.14 Å2
Dissociation energy (ΔGdiss): -0.69 kcal/mol
Dissociation entropy (TΔSdiss): 105.31 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-100463

Macromolecules

HLA class I histocompatibility antigen, A alpha chain
Chain: A
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Pfam:
InterPro:
CATH:
SCOP:
HLA class I histocompatibility antigen, A alpha chain in PDB entry 1ao7, assembly 1, front view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 1ao7, assembly 1, side view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 1ao7, assembly 1, top view.
Molecule details ›

Search similar proteins

Beta-2-microglobulin
Chain: B
Length: 100 amino acids
Theoretical weight: 11.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
SCOP: C1 set domains (antibody constant domain-like)
Beta-2-microglobulin in PDB entry 1ao7, assembly 1, front view.
Beta-2-microglobulin in PDB entry 1ao7, assembly 1, side view.
Beta-2-microglobulin in PDB entry 1ao7, assembly 1, top view.
Molecule details ›

Search similar proteins

Protein Tax-1
Chain: C
Length: 9 amino acids
Theoretical weight: 1.07 KDa
Source organism: Human T-cell leukemia virus type I
Expression system: Not provided
UniProt:
  • Canonical: P14079 (Residues: 11-19; Coverage: 3%)
Gene name: tax
Protein Tax-1 in PDB entry 1ao7, assembly 1, front view.
Protein Tax-1 in PDB entry 1ao7, assembly 1, side view.
Protein Tax-1 in PDB entry 1ao7, assembly 1, top view.
Molecule details ›

Search similar proteins

T cell receptor alpha chain constant; T cell receptor alpha variable 12-2
Chain: D
Length: 204 amino acids
Theoretical weight: 22.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A075B6T6 (Residues: 23-112; Coverage: 97%)
  • Canonical: P01848 (Residues: 1-93; Coverage: 66%)
    • nullnull
Gene names: TCRA, TRAC, TRAV12-2
Pfam:
InterPro:
CATH: Immunoglobulins
SCOP: V set domains (antibody variable domain-like)
T cell receptor alpha chain constant in PDB entry 1ao7, assembly 1, front view.
T cell receptor alpha chain constant in PDB entry 1ao7, assembly 1, side view.
T cell receptor alpha chain constant in PDB entry 1ao7, assembly 1, top view.
Molecule details ›

Search similar proteins

T cell receptor beta constant 2; T cell receptor beta variable 6-5
Chain: E
Length: 245 amino acids
Theoretical weight: 27.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A0K0K1A5 (Residues: 20-114; Coverage: 100%)
  • Canonical: A0A5B9 (Residues: 1-129; Coverage: 73%)
    • nullnull
Gene names: TCRBC2, TRBC2, TRBV6-5
Pfam:
InterPro:
CATH: Immunoglobulins
SCOP:
T cell receptor beta constant 2 in PDB entry 1ao7, assembly 1, front view.
T cell receptor beta constant 2 in PDB entry 1ao7, assembly 1, side view.
T cell receptor beta constant 2 in PDB entry 1ao7, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links