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ACTIVITY AND SPECIFICITY OF HUMAN ALDOLASES

Source organism: Homo sapiens
Biochemical function: fructose binding
Biological process: protein homotetramerization
Cellular component: ficolin-1-rich granule lumen

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EC 4.1.2.13: Fructose-bisphosphate aldolase

Reaction catalysed:
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate
Systematic name:
D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)
Alternative Name(s):
  • 1,6-diphosphofructose aldolase
  • Aldolase
  • D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase
  • Diphosphofructose aldolase
  • Fructoaldolase
  • Fructose 1,6-diphosphate aldolase
  • Fructose 1-monophosphate aldolase
  • Fructose 1-phosphate aldolase
  • Fructose diphosphate aldolase
  • Fructose-1,6-bisphosphate triosephosphate-lyase
  • Ketose 1-phosphate aldolase
  • Phosphofructoaldolase
  • SMALDO
  • Zymohexase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00274
Domain description: Fructose-bisphosphate aldolase class-I
Occurring in:
  1. Fructose-bisphosphate aldolase A
The deposited structure of PDB entry 1ald contains 1 copy of Pfam domain PF00274 (Fructose-bisphosphate aldolase class-I) in Fructose-bisphosphate aldolase A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000741
Domain description: Fructose-bisphosphate aldolase, class-I
Occurring in:
  1. Fructose-bisphosphate aldolase A
IPR029768
Domain description: Fructose-bisphosphate aldolase class-I active site
Occurring in:
  1. Fructose-bisphosphate aldolase A
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Fructose-bisphosphate aldolase A

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Fructose-bisphosphate aldolase A
The deposited structure of PDB entry 1ald contains 1 copy of CATH domain 3.20.20.70 (TIM Barrel) in Fructose-bisphosphate aldolase A. Showing 1 copy in chain A.
SCOP SCOP annotation
51570
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Aldolase
Occurring in:
  1. Fructose-bisphosphate aldolase A
The deposited structure of PDB entry 1ald contains 1 copy of SCOP domain 51570 (Class I aldolase) in Fructose-bisphosphate aldolase A. Showing 1 copy in chain A.

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