Function and Biology

THE 1.8 ANGSTROM CRYSTAL STRUCTURE OF THE DIMERIC PEROXISOMAL THIOLASE OF SACCHAROMYCES CEREVISIAE

Source organism: Saccharomyces cerevisiae
Biochemical function: transferase activity
Biological process: fatty acid metabolic process
Cellular component: peroxisome

EC 2.3.1.16: Acetyl-CoA C-acyltransferase

Reaction catalysed:
Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
Systematic name:
Acyl-CoA:acetyl-CoA C-acyltransferase
Alternative Name(s):
  • 3-ketoacyl CoA thiolase
  • 3-ketoacyl coenzyme A thiolase
  • 3-ketoacyl thiolase
  • 3-ketoacyl-CoA thiolase
  • 3-ketothiolase
  • 3-oxoacyl-CoA thiolase
  • 3-oxoacyl-coenzyme A thiolase
  • 6-oxoacyl-CoA thiolase
  • Beta-ketoacyl coenzyme A thiolase
  • Beta-ketoacyl-CoA thiolase
  • Beta-ketoadipyl coenzyme A thiolase
  • Beta-ketoadipyl-CoA thiolase
  • Beta-ketothiolase
  • KAT
  • Acetoacetyl-CoA beta-ketothiolase
  • Acetyl-CoA acyltransferase
  • Ketoacyl-CoA acyltransferase
  • Ketoacyl-coenzyme A thiolase
  • Long-chain 3-oxoacyl-CoA thiolase
  • Oxoacyl-coenzyme A thiolase
  • Pro-3-ketoacyl-CoA thiolase
  • Thiolase I
  • 2-methylacetoacetyl-CoA thiolase

Sequence families

Pfam Protein families (Pfam)
PF00108
Domain description: Thiolase, N-terminal domain
Occurring in:
  1. 3-ketoacyl-CoA thiolase, peroxisomal
1 copy of Pfam domain PF00108 (Thiolase, N-terminal domain) in 3-ketoacyl-CoA thiolase, peroxisomal in PDB 1afw.

PF02803
Domain description: Thiolase, C-terminal domain
Occurring in:
  1. 3-ketoacyl-CoA thiolase, peroxisomal
1 copy of Pfam domain PF02803 (Thiolase, C-terminal domain) in 3-ketoacyl-CoA thiolase, peroxisomal in PDB 1afw.

InterPro InterPro annotations
IPR016039
Domain description: Thiolase-like
Occurring in:
  1. 3-ketoacyl-CoA thiolase, peroxisomal
IPR002155
Domain description: Thiolase
Occurring in:
  1. 3-ketoacyl-CoA thiolase, peroxisomal
IPR020617
Domain description: Thiolase, C-terminal
Occurring in:
  1. 3-ketoacyl-CoA thiolase, peroxisomal
IPR020616
Domain description: Thiolase, N-terminal
Occurring in:
  1. 3-ketoacyl-CoA thiolase, peroxisomal
IPR020615
Domain description: Thiolase, acyl-enzyme intermediate active site
Occurring in:
  1. 3-ketoacyl-CoA thiolase, peroxisomal
IPR020613
Domain description: Thiolase, conserved site
Occurring in:
  1. 3-ketoacyl-CoA thiolase, peroxisomal
IPR020610
Domain description: Thiolase, active site
Occurring in:
  1. 3-ketoacyl-CoA thiolase, peroxisomal

Structure domain

CATH CATH domain
3.40.47.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Peroxisomal Thiolase; Chain A, domain 1
Homology: Peroxisomal Thiolase; Chain A, domain 1
Occurring in:
  1. 3-ketoacyl-CoA thiolase, peroxisomal
2 copies of CATH domain 3.40.47.10 (Peroxisomal Thiolase; Chain A, domain 1) in 3-ketoacyl-CoA thiolase, peroxisomal in PDB 1afw.
SCOP SCOP annotation
53902
Class: Alpha and beta proteins (a/b)
Fold: Thiolase-like
Superfamily: Thiolase-like
Occurring in:
  1. 3-ketoacyl-CoA thiolase, peroxisomal
2 copies of SCOP domain 53902 (Thiolase-related) in 3-ketoacyl-CoA thiolase, peroxisomal in PDB 1afw.