PDBe 1ad5

X-ray diffraction
2.6Å resolution

SRC FAMILY KINASE HCK-AMP-PNP COMPLEX

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of the Src family tyrosine kinase Hck.
Nature 385 602-9 (1997)
PMID: 9024658

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase HCK Chains: A, B
Molecule details ›
Chains: A, B
Length: 438 amino acids
Theoretical weight: 50.3 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08631 (Residues: 79-526; Coverage: 83%)
Gene name: HCK
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P212121
Unit cell:
a: 72.767Å b: 92.36Å c: 178.29Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.239 0.307
Expression system: Spodoptera frugiperda