PDBe 1ab8

X-ray diffraction
2.2Å resolution

RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX

Released:
Source organism: Rattus norvegicus
Primary publication:
Structure of the adenylyl cyclase catalytic core.
Nature 386 247-53 (1997)
PMID: 9069282

Function and Biology Details

Reaction catalysed:
ATP = 3',5'-cyclic AMP + diphosphate. 
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenylate cyclase type 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 220 amino acids
Theoretical weight: 24.45 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26769 (Residues: 871-1090; Coverage: 20%)
Gene name: Adcy2
Sequence domains: Adenylate and Guanylate cyclase catalytic domain
Structure domains: Adenylyl Cyclase, chain A

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P43212
Unit cell:
a: 81.3Å b: 81.3Å c: 180.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.219 0.284
Expression system: Escherichia coli BL21(DE3)