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REDUCED FORM OF FORMATE DEHYDROGENASE H FROM E. COLI

Source organism: Escherichia coli
Biochemical function: 4 iron, 4 sulfur cluster binding
Biological process: cellular respiration
Cellular component: oxidoreductase complex

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EC 1.17.98.4: Formate dehydrogenase (acceptor)

Reaction catalysed:
Formate + an [oxidized hydrogenase] = CO(2) + a [reduced hydrogenase]
Systematic name:
Formate:[oxidized hydrogenase] oxidoreductase
Alternative Name(s):
  • FDH-H
  • FDH-O
  • FDHH
  • Formate dehydrogenase H
  • Formate dehydrogenase O

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01568
Domain description: Molydopterin dinucleotide binding domain
Occurring in:
  1. Formate dehydrogenase H
The deposited structure of PDB entry 1aa6 contains 1 copy of Pfam domain PF01568 (Molydopterin dinucleotide binding domain) in Formate dehydrogenase H. Showing 1 copy in chain A.

PF00384
Domain description: Molybdopterin oxidoreductase
Occurring in:
  1. Formate dehydrogenase H
The deposited structure of PDB entry 1aa6 contains 1 copy of Pfam domain PF00384 (Molybdopterin oxidoreductase) in Formate dehydrogenase H. Showing 1 copy in chain A.

PF04879
Domain description: Molybdopterin oxidoreductase Fe4S4 domain
Occurring in:
  1. Formate dehydrogenase H
The deposited structure of PDB entry 1aa6 contains 1 copy of Pfam domain PF04879 (Molybdopterin oxidoreductase Fe4S4 domain) in Formate dehydrogenase H. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006963
Domain description: Molybdopterin oxidoreductase, 4Fe-4S domain
Occurring in:
  1. Formate dehydrogenase H
IPR006655
Domain description: Molybdopterin oxidoreductase, prokaryotic, conserved site
Occurring in:
  1. Formate dehydrogenase H
IPR006657
Domain description: Molybdopterin dinucleotide-binding domain
Occurring in:
  1. Formate dehydrogenase H
IPR041925
Domain description: Formate dehydrogenase H, molybdopterin-binding domain
Occurring in:
  1. Formate dehydrogenase H
IPR009010
Domain description: Aspartate decarboxylase-like domain superfamily
Occurring in:
  1. Formate dehydrogenase H
IPR006656
Domain description: Molybdopterin oxidoreductase
Occurring in:
  1. Formate dehydrogenase H
IPR041924
Domain description: Formate dehydrogenase H, N-terminal
Occurring in:
  1. Formate dehydrogenase H
IPR027467
Domain description: Molybdopterin oxidoreductase, molybdopterin cofactor binding site
Occurring in:
  1. Formate dehydrogenase H
IPR006478
Domain description: Formate dehydrogenase, alpha subunit
Occurring in:
  1. Formate dehydrogenase H

Structure domains

CATH CATH domains
3.40.50.740
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Formate dehydrogenase H
The deposited structure of PDB entry 1aa6 contains 1 copy of CATH domain 3.40.50.740 (Rossmann fold) in Formate dehydrogenase H. Showing 1 copy in chain A.
2.40.40.20
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Barwin-like endoglucanases
Homology: Barwin-like endoglucanases
Occurring in:
  1. Formate dehydrogenase H
The deposited structure of PDB entry 1aa6 contains 1 copy of CATH domain 2.40.40.20 (Barwin-like endoglucanases) in Formate dehydrogenase H. Showing 1 copy in chain A.
3.40.228.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Dimethylsulfoxide Reductase; domain 2
Homology: Dimethylsulfoxide Reductase, domain 2
Occurring in:
  1. Formate dehydrogenase H
The deposited structure of PDB entry 1aa6 contains 1 copy of CATH domain 3.40.228.10 (Dimethylsulfoxide Reductase; domain 2) in Formate dehydrogenase H. Showing 1 copy in chain A.
2.20.25.90
Class: Mainly Beta
Architecture: Single Sheet
Topology: N-terminal domain of TfIIb
Homology: ADC-like domains
Occurring in:
  1. Formate dehydrogenase H
The deposited structure of PDB entry 1aa6 contains 1 copy of CATH domain 2.20.25.90 (N-terminal domain of TfIIb) in Formate dehydrogenase H. Showing 1 copy in chain A.
SCOP SCOP annotations
50696
Class: All beta proteins
Fold: Double psi beta-barrel
Superfamily: ADC-like
Occurring in:
  1. Formate dehydrogenase H
The deposited structure of PDB entry 1aa6 contains 1 copy of SCOP domain 50696 (Formate dehydrogenase/DMSO reductase, C-terminal domain) in Formate dehydrogenase H. Showing 1 copy in chain A.
53707
Class: Alpha and beta proteins (a/b)
Fold: Formate dehydrogenase/DMSO reductase, domains 1-3
Superfamily: Formate dehydrogenase/DMSO reductase, domains 1-3
Occurring in:
  1. Formate dehydrogenase H
The deposited structure of PDB entry 1aa6 contains 1 copy of SCOP domain 53707 (Formate dehydrogenase/DMSO reductase, domains 1-3) in Formate dehydrogenase H. Showing 1 copy in chain A.

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