PDBe 1a85

X-ray diffraction
2Å resolution

MMP8 WITH MALONIC AND ASPARAGINE BASED INHIBITOR

Released:

Function and Biology Details

Reaction catalysed:
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutrophil collagenase Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 17.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P22894 (Residues: 105-262; Coverage: 35%)
Gene names: CLG1, MMP8
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 33.14Å b: 69.43Å c: 72.62Å
α: 90° β: 90° γ: 90°