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CRYSTAL STRUCTURE OF THE TANDEM SH2 DOMAIN OF THE SYK KINASE BOUND TO A DUALLY TYROSINE-PHOSPHORYLATED ITAM

X-ray diffraction
3Å resolution
PDB entry 1a81 coloured by chain, front view.
PDB entry 1a81 coloured by chain, side view.
PDB entry 1a81 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero hexamer
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: T-cell surface glycoprotein CD3 epsilon chain and Tyrosine-protein kinase SYK
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Multimeric state: hetero hexamer
Accessible surface area: 35894.37 Å2
Buried surface area: 8961.01 Å2
Dissociation area: 1,296.56 Å2
Dissociation energy (ΔGdiss): -9.71 kcal/mol
Dissociation entropy (TΔSdiss): 26.14 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139753
Assembly 2
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Assembly Name: T-cell surface glycoprotein CD3 epsilon chain and Tyrosine-protein kinase SYK
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Multimeric state: hetero hexamer
Accessible surface area: 37634.29 Å2
Buried surface area: 9141.53 Å2
Dissociation area: 1,239.01 Å2
Dissociation energy (ΔGdiss): -12.04 kcal/mol
Dissociation entropy (TΔSdiss): 26.37 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139753
Assembly 3 (preferred)
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Assembly Name: T-cell surface glycoprotein CD3 epsilon chain and Tyrosine-protein kinase SYK
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Multimeric state: hetero dimer
Accessible surface area: 13830.83 Å2
Buried surface area: 2192.42 Å2
Dissociation area: 1,096.21 Å2
Dissociation energy (ΔGdiss): 14.72 kcal/mol
Dissociation entropy (TΔSdiss): 9.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139750
Assembly 4
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Assembly Name: T-cell surface glycoprotein CD3 epsilon chain and Tyrosine-protein kinase SYK
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Multimeric state: hetero dimer
Accessible surface area: 12123.41 Å2
Buried surface area: 2164.43 Å2
Dissociation area: 1,082.22 Å2
Dissociation energy (ΔGdiss): 13.35 kcal/mol
Dissociation entropy (TΔSdiss): 9.54 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139750
Assembly 5
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Assembly Name: T-cell surface glycoprotein CD3 epsilon chain and Tyrosine-protein kinase SYK
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Multimeric state: hetero dimer
Accessible surface area: 12299.3 Å2
Buried surface area: 2132.6 Å2
Dissociation area: 1,066.3 Å2
Dissociation energy (ΔGdiss): 11.62 kcal/mol
Dissociation entropy (TΔSdiss): 9.45 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139750
Assembly 6
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Assembly Name: T-cell surface glycoprotein CD3 epsilon chain and Tyrosine-protein kinase SYK
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Multimeric state: hetero dimer
Accessible surface area: 13944.7 Å2
Buried surface area: 2210.38 Å2
Dissociation area: 1,105.19 Å2
Dissociation energy (ΔGdiss): 11.32 kcal/mol
Dissociation entropy (TΔSdiss): 9.56 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139750
Assembly 7
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Assembly Name: T-cell surface glycoprotein CD3 epsilon chain and Tyrosine-protein kinase SYK
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Multimeric state: hetero dimer
Accessible surface area: 14064.78 Å2
Buried surface area: 2070.86 Å2
Dissociation area: 1,035.43 Å2
Dissociation energy (ΔGdiss): 11.09 kcal/mol
Dissociation entropy (TΔSdiss): 9.5 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139750
Assembly 8
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Assembly Name: T-cell surface glycoprotein CD3 epsilon chain and Tyrosine-protein kinase SYK
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Multimeric state: hetero dimer
Accessible surface area: 12336.78 Å2
Buried surface area: 2260.72 Å2
Dissociation area: 1,130.36 Å2
Dissociation energy (ΔGdiss): 11.23 kcal/mol
Dissociation entropy (TΔSdiss): 9.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139750

Macromolecules

Tyrosine-protein kinase SYK
Chains: A, C, E, G, I, K
Length: 254 amino acids
Theoretical weight: 28.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43405 (Residues: 9-262; Coverage: 40%)
Gene name: SYK
Pfam: SH2 domain
InterPro:
CATH:
SCOP: SH2 domain
Tyrosine-protein kinase SYK in PDB entry 1a81, assembly 3, front view.
Tyrosine-protein kinase SYK in PDB entry 1a81, assembly 3, side view.
Tyrosine-protein kinase SYK in PDB entry 1a81, assembly 3, top view.
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T-cell surface glycoprotein CD3 epsilon chain
Chains: B, D, F, H, J, L
Length: 18 amino acids
Theoretical weight: 2.28 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P07766 (Residues: 186-203; Coverage: 10%)
Gene names: CD3E, T3E
Pfam: Immunoreceptor tyrosine-based activation motif
InterPro: Phosphorylated immunoreceptor signalling ITAM
T-cell surface glycoprotein CD3 epsilon chain in PDB entry 1a81, assembly 3, front view.
T-cell surface glycoprotein CD3 epsilon chain in PDB entry 1a81, assembly 3, side view.
T-cell surface glycoprotein CD3 epsilon chain in PDB entry 1a81, assembly 3, top view.
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