› 1a6e

X-ray diffraction
3.2Å resolution

THERMOSOME-MG-ADP-ALF3 COMPLEX

Released:
DOI: 10.2210/pdb1a6e/pdb
PDB entry 1a6e coloured by chain, front view.
PDB entry 1a6e coloured by chain, side view.
PDB entry 1a6e coloured by chain, top view.
Source organism: Thermoplasma acidophilum
Primary publication:
Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT.
Ditzel L, Löwe J, Stock D, Stetter KO, Huber H, Huber R, Steinbacher S
Cell 93 125-38 (1998)
PMID: 9546398

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
hetero hexadecamer
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155724 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thermosome subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 545 amino acids
Theoretical weight: 58.32 KDa
Source organism: Thermoplasma acidophilum
UniProt:
  • Canonical: P48424 (Residues: 1-545; Coverage: 100%)
Gene names: Ta0980, thsA
Sequence domains: TCP-1/cpn60 chaperonin family
Structure domains:
Thermosome subunit beta Chain: B
Molecule details ›
Chain: B
Length: 543 amino acids
Theoretical weight: 58.55 KDa
Source organism: Thermoplasma acidophilum
UniProt:
  • Canonical: P48425 (Residues: 1-543; Coverage: 100%)
Gene names: Ta1276, thsB
Sequence domains: TCP-1/cpn60 chaperonin family
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MG 2 x MG
Ligand ADP 2 x ADP
Ligand AF3 2 x AF3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: I422
Unit cell:
a: 167.8Å b: 167.8Å c: 202.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.181 0.285

Quick links

Citations

57 review citations

Pathways of chaperone-mediated protein folding in the cytosol.
Young et al. (2004)
56 more

12 mentions without citation

Lessons from making the Structural Classification of Proteins (SCOP) and their implications for protein structure modelling.
Andreeva A. (2016)
11 more