PDBe 1a52

X-ray diffraction
2.8Å resolution

ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN COMPLEXED TO ESTRADIOL

Released:
Source organism: Homo sapiens
Primary publication:
Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains.
Proc. Natl. Acad. Sci. U.S.A. 95 5998-6003 (1998)
PMID: 9600906

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 258 amino acids
Theoretical weight: 29.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 297-554; Coverage: 43%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: R32
Unit cell:
a: 147Å b: 147Å c: 168.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.223 0.274
Expression system: Escherichia coli