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TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS

Source organism: Vaccinia virus
Biochemical function: DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological process: DNA topological change
Cellular component: not assigned

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EC 5.6.2.1: DNA topoisomerase

Reaction catalysed:
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
Systematic name:
DNA topoisomerase
Alternative Name(s):
  • DNA topoisomerase I
  • Nicking-closing enzyme
  • Omega-protein
  • Relaxing enzyme
  • Swivelase
  • Type I DNA topoisomerase
  • Untwisting enzyme

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01028
Domain description: Eukaryotic DNA topoisomerase I, catalytic core
Occurring in:
  1. DNA topoisomerase 1B
The deposited structure of PDB entry 1a41 contains 1 copy of Pfam domain PF01028 (Eukaryotic DNA topoisomerase I, catalytic core) in DNA topoisomerase 1B. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001631
Domain description: DNA topoisomerase I
Occurring in:
  1. DNA topoisomerase 1B
IPR013500
Domain description: DNA topoisomerase I, catalytic core, eukaryotic-type
Occurring in:
  1. DNA topoisomerase 1B
IPR018521
Domain description: DNA topoisomerase I, active site
Occurring in:
  1. DNA topoisomerase 1B
IPR011010
Domain description: DNA breaking-rejoining enzyme, catalytic core
Occurring in:
  1. DNA topoisomerase 1B
IPR014711
Domain description: DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
Occurring in:
  1. DNA topoisomerase 1B

Structure domains

CATH CATH domains
1.20.120.380
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Four Helix Bundle (Hemerythrin (Met), subunit A)
Homology: Type 1-topoisomerase catalytic fragment, domain 2
Occurring in:
  1. DNA topoisomerase 1B
The deposited structure of PDB entry 1a41 contains 1 copy of CATH domain 1.20.120.380 (Four Helix Bundle (Hemerythrin (Met), subunit A)) in DNA topoisomerase 1B. Showing 1 copy in chain A.
3.90.15.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Topoisomerase I; Chain A, domain 3
Homology: Topoisomerase I; Chain A, domain 3
Occurring in:
  1. DNA topoisomerase 1B
The deposited structure of PDB entry 1a41 contains 1 copy of CATH domain 3.90.15.10 (Topoisomerase I; Chain A, domain 3) in DNA topoisomerase 1B. Showing 1 copy in chain A.
SCOP SCOP annotation
56361
Class: Alpha and beta proteins (a+b)
Fold: DNA breaking-rejoining enzymes
Superfamily: DNA breaking-rejoining enzymes
Occurring in:
  1. DNA topoisomerase 1B
The deposited structure of PDB entry 1a41 contains 1 copy of SCOP domain 56361 (Eukaryotic DNA topoisomerase I, catalytic core) in DNA topoisomerase 1B. Showing 1 copy in chain A.

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