EC 2.4.2.30: NAD(+) ADP-ribosyltransferase
Reaction catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Systematic name:
NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
Alternative Name(s):
- ADP-ribosyltransferase (polymerizing)
- NAD(+):poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
- NAD(+):poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
- Poly(ADP-ribose) synthase
- Poly(ADP-ribose) synthetase
- Poly(ADP-ribose)polymerase
- Poly(adenosine diphosphate ribose) polymerase
GO terms
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 1a26 contains 1 copy of Pfam domain PF00644 (Poly(ADP-ribose) polymerase catalytic domain) in Poly [ADP-ribose] polymerase 1. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1a26_1_A_Pfam_PF00644_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1a26</span> contains 1 copy of Pfam domain <span class='highlight'>PF00644 (Poly(ADP-ribose) polymerase catalytic domain)</span> in <span class='highlight'>Poly [ADP-ribose] polymerase 1</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")
![The deposited structure of PDB entry 1a26 contains 1 copy of Pfam domain PF02877 (Poly(ADP-ribose) polymerase, regulatory domain) in Poly [ADP-ribose] polymerase 1. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1a26_1_A_Pfam_PF02877_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1a26</span> contains 1 copy of Pfam domain <span class='highlight'>PF02877 (Poly(ADP-ribose) polymerase, regulatory domain)</span> in <span class='highlight'>Poly [ADP-ribose] polymerase 1</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")
InterPro annotations
Structure domains
CATH domains
3.90.228.10
Class:
Alpha Beta
Architecture:
Alpha-Beta Complex
Topology:
Phosphoenolpyruvate Carboxykinase; domain 3
Homology:
Phosphoenolpyruvate Carboxykinase; domain 3
Occurring in:
![The deposited structure of PDB entry 1a26 contains 1 copy of CATH domain 3.90.228.10 (Phosphoenolpyruvate Carboxykinase; domain 3) in Poly [ADP-ribose] polymerase 1. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1a26_1_A_CATH_3.90.228.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1a26</span> contains 1 copy of CATH domain <span class='highlight'>3.90.228.10 (Phosphoenolpyruvate Carboxykinase; domain 3)</span> in <span class='highlight'>Poly [ADP-ribose] polymerase 1</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")
![The deposited structure of PDB entry 1a26 contains 1 copy of CATH domain 1.20.142.10 (Poly(ADP-ribose) Polymerase; domain 1) in Poly [ADP-ribose] polymerase 1. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1a26_1_A_CATH_1.20.142.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1a26</span> contains 1 copy of CATH domain <span class='highlight'>1.20.142.10 (Poly(ADP-ribose) Polymerase; domain 1)</span> in <span class='highlight'>Poly [ADP-ribose] polymerase 1</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")
SCOP annotations![The deposited structure of PDB entry 1a26 contains 1 copy of SCOP domain 56416 (Poly(ADP-ribose) polymerase, C-terminal domain) in Poly [ADP-ribose] polymerase 1. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1a26_1_A_SCOP_56416_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1a26</span> contains 1 copy of SCOP domain <span class='highlight'>56416 (Poly(ADP-ribose) polymerase, C-terminal domain)</span> in <span class='highlight'>Poly [ADP-ribose] polymerase 1</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")
![The deposited structure of PDB entry 1a26 contains 1 copy of SCOP domain 47588 (Domain of poly(ADP-ribose) polymerase) in Poly [ADP-ribose] polymerase 1. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/1a26_1_A_SCOP_47588_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>1a26</span> contains 1 copy of SCOP domain <span class='highlight'>47588 (Domain of poly(ADP-ribose) polymerase)</span> in <span class='highlight'>Poly [ADP-ribose] polymerase 1</span>. Showing 1 copy in chain <span class='highlight'>A</span>.")