PDBe 1a26

X-ray diffraction
2.25Å resolution

THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH CARBA-NAD

Released:

Function and Biology Details

Reaction catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor. 
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Poly [ADP-ribose] polymerase 1 Chain: A
Molecule details ›
Chain: A
Length: 361 amino acids
Theoretical weight: 40.42 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P26446 (Residues: 652-1011; Coverage: 36%)
Gene names: ADPRT, PARP1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SIEMENS
Spacegroup: P212121
Unit cell:
a: 59.04Å b: 64.44Å c: 96.72Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.168 0.236
Expression system: Spodoptera frugiperda