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NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, FAMILY OF 25 STRUCTURES

Solution NMR
PDB entry 1a0n coloured by chain, ensemble of 25 models, front view.
PDB entry 1a0n coloured by chain, ensemble of 25 models, side view.
PDB entry 1a0n coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase Fyn and Phosphatidylinositol 3-kinase regulatory subunit alpha
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Multimeric state: hetero dimer
Accessible surface area: 4919.74 Å2
Buried surface area: 751.94 Å2
Dissociation area: 375.97 Å2
Dissociation energy (ΔGdiss): -1.71 kcal/mol
Dissociation entropy (TΔSdiss): 7.72 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138964

Macromolecules

Phosphatidylinositol 3-kinase regulatory subunit alpha
Chain: A
Length: 14 amino acids
Theoretical weight: 1.41 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P27986 (Residues: 91-104; Coverage: 2%)
Gene names: GRB1, PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 1a0n, assembly 1, front view.
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 1a0n, assembly 1, side view.
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 1a0n, assembly 1, top view.
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Tyrosine-protein kinase Fyn
Chain: B
Length: 69 amino acids
Theoretical weight: 7.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06241 (Residues: 80-148; Coverage: 13%)
Gene name: FYN
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains
SCOP: SH3-domain
Tyrosine-protein kinase Fyn in PDB entry 1a0n, assembly 1, front view.
Tyrosine-protein kinase Fyn in PDB entry 1a0n, assembly 1, side view.
Tyrosine-protein kinase Fyn in PDB entry 1a0n, assembly 1, top view.
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