Function and Biology

STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA

Source organism: Homo sapiens
Biochemical function: DNA binding
Biological process: regulation of transcription, DNA-templated
Cellular component: transcription factor complex

Sequence family

Pfam Protein family (Pfam)
PF00554
Domain description: Rel homology DNA-binding domain
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
1 copy of Pfam domain PF00554 (Rel homology DNA-binding domain) in Nuclear factor of activated T-cells, cytoplasmic 2 in PDB 1a02.

InterPro InterPro annotations
IPR004827
Domain description: Basic-leucine zipper domain
Occurring in:
  1. Proto-oncogene c-Fos
  2. Transcription factor AP-1
IPR008366
Domain description: Nuclear factor of activated T cells (NFAT)
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR000837
Domain description: AP-1 transcription factor
Occurring in:
  1. Proto-oncogene c-Fos
IPR002112
Domain description: Transcription factor Jun
Occurring in:
  1. Transcription factor AP-1
IPR011539
Domain description: Rel homology domain (RHD), DNA-binding domain
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR008967
Domain description: p53-like transcription factor, DNA-binding
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR008917
Domain description: Transcription factor, Skn-1-like, DNA-binding domain superfamily
Occurring in:
  1. Transcription factor AP-1
IPR002909
Domain description: IPT domain
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR029816
Domain description: c-Fos/v-Fos
Occurring in:
  1. Proto-oncogene c-Fos
IPR037059
Domain description: Rel homology domain (RHD), DNA-binding domain superfamily
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR015558
Domain description: Transcription Factor c-Jun/v-Jun
Occurring in:
  1. Transcription factor AP-1
IPR032397
Domain description: Rel homology dimerisation domain
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2

Structure domains

CATH CATH domains
1.20.5.170
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Proto-oncogene c-Fos
  2. Transcription factor AP-1
2 copies of CATH domain 1.20.5.170 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Transcription factor AP-1 in PDB 1a02.
1 copy of CATH domain 1.20.5.170 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Proto-oncogene c-Fos in PDB 1a02.
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Nuclear factor of activated T-cells, cytoplasmic 2 in PDB 1a02.
2.60.40.340
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
1 copy of CATH domain 2.60.40.340 (Immunoglobulin-like) in Nuclear factor of activated T-cells, cytoplasmic 2 in PDB 1a02.
SCOP SCOP annotations
57960
Class: Coiled coil proteins
Fold: Parallel coiled-coil
Superfamily: Leucine zipper domain
Occurring in:
  1. Proto-oncogene c-Fos
  2. Transcription factor AP-1
2 copies of SCOP domain 57960 (Leucine zipper domain) in Transcription factor AP-1 in PDB 1a02.
1 copy of SCOP domain 57960 (Leucine zipper domain) in Proto-oncogene c-Fos in PDB 1a02.
81279
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: E set domains
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
1 copy of SCOP domain 81279 (NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain) in Nuclear factor of activated T-cells, cytoplasmic 2 in PDB 1a02.
81315
Class: All beta proteins
Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily: p53-like transcription factors
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
1 copy of SCOP domain 81315 (Rel/Dorsal transcription factors, DNA-binding domain) in Nuclear factor of activated T-cells, cytoplasmic 2 in PDB 1a02.