Structure analysis

STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA

X-ray diffraction
2.7Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 3 distinct polypeptide molecules
2 distinct DNA molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 26400 Å2
Buried surface area: 9500 Å2
Dissociation area: 2,900 Å2
Dissociation energy (ΔGdiss): 16 kcal/mol
Dissociation entropy (TΔSdiss): 25 kcal/mol
Interface energy (ΔGint): -43 kcal/mol
Symmetry number: 1

Macromolecules

Chain: F
Length: 56 amino acids
Theoretical weight: 6.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01100 (Residues: 138-193; Coverage: 15%)
Gene names: FOS, G0S7
InterPro:
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
SCOP: Leucine zipper domain

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Search similar proteins

Name: DNA (5'-D(*DAP*DAP*DCP*DTP*DAP*DTP*DGP*DAP*DAP*DAP*DCP*DAP*DAP*DAP*DTP*DTP*DTP*DTP*DCP*DC)-3')
Representative chains: B
Length: 20 nucleotides
Theoretical weight: 6.08 KDa

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Name: DNA (5'-D(*DTP*DTP*DGP*DGP*DAP*DAP*DAP*DAP*DTP*DTP*DTP*DGP*DTP*DTP*DTP*DCP*DAP*DTP*DAP*DG)-3')
Representative chains: A
Length: 20 nucleotides
Theoretical weight: 6.18 KDa

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