PDBe 1zsj

X-ray diffraction
1.9Å resolution

Crystal Structure of the Catalytic Domain of Coagulation Factor XI in complex with N-(7-Carbamimidoyl-naphthalen-1-yl)-3-hydroxy-2-methyl-benzamide

Source organism: Homo sapiens
Entry authors: Guo Z, Bannister T, Noll R, Jin L, Rynkiewicz M, Bibbins F, Magee S, Gorga J, Babine RE, Strickler JE, Meyers HV, Abdel-Meguid SS

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Coagulation factor XIa light chain Chain: A
Molecule details ›
Chain: A
Length: 238 amino acids
Theoretical weight: 26.75 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
  • Canonical: NEW P03951 (Residues: 388-625; Coverage: 39%)
Gene name: F11
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: I23
Unit cell:
a: 120.74Å b: 120.74Å c: 120.74Å
α: 90° β: 90° γ: 90°
R R work R free
0.188 0.188 0.207
Expression system: Komagataella pastoris