PDBe 1zrk

X-ray diffraction
2.3Å resolution

Factor XI complexed with 3-hydroxypropyl 3-(7-amidinonaphthalene-1-carboxamido)benzenesulfonate

Released:
Source organism: Homo sapiens
Entry authors: Guo Z, Bannister T, Noll R, Jin L, Rynkiewicz MJ, Bibbins F, Magee S, Gorga J, Babine R, Strickler J

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Coagulation factor XIa light chain Chain: A
Molecule details ›
Chain: A
Length: 238 amino acids
Theoretical weight: 26.8 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: NEW P03951 (Residues: 388-625; Coverage: 39%)
Gene name: F11
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: I23
Unit cell:
a: 120.899Å b: 120.899Å c: 120.899Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 0.235
Expression system: Komagataella pastoris