PDBe 1zp0

X-ray diffraction
3.5Å resolution

Crystal Structure of Mitochondrial Respiratory Complex II bound with 3-nitropropionate and 2-thenoyltrifluoroacetone

Released:
Source organism: Sus scrofa

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Chain: A
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Chain: B
Molecule details ›
Chain: B
Length: 252 amino acids
Theoretical weight: 28.79 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q007T0 (Residues: 29-279; Coverage: 90%)
Gene name: SDHB
Sequence domains:
Structure domains:
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Chain: C
Molecule details ›
Chain: C
Length: 140 amino acids
Theoretical weight: 15.3 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: D0VWV4 (Residues: 30-169; Coverage: 83%)
Gene name: SDHC
Sequence domains: Succinate dehydrogenase/Fumarate reductase transmembrane subunit
Structure domains:
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Chain: D
Molecule details ›
Chain: D
Length: 103 amino acids
Theoretical weight: 10.94 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: A5GZW8 (Residues: 57-159; Coverage: 65%)
Gene name: SDHD
Structure domains: Fumarate reductase/succinate dehydrogenase, transmembrane subunit

Ligands and Environments


Cofactor: Ligand HEM 1 x HEM

Cofactor: Ligand FAD 1 x FAD

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 70.33Å b: 83.531Å c: 294.18Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.302 0.268 0.293