PDBe 1zoq

X-ray diffraction
2.37Å resolution

IRF3-CBP complex

Released:
Source organism: Homo sapiens
Primary publication:
IRF-3 releases its inhibitions.
Structure 13 1235-6 (2005)
PMID: 16154077

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interferon regulatory factor 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 191 amino acids
Theoretical weight: 21.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW Q14653 (Residues: 196-386; Coverage: 45%)
Gene name: IRF3
Sequence domains: Interferon-regulatory factor 3
Structure domains: Tumour Suppressor Smad4
CREB-binding protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 47 amino acids
Theoretical weight: 5.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW Q92793 (Residues: 2065-2111; Coverage: 2%)
Gene names: CBP, CREBBP
Structure domains: Nuclear receptor coactivator, CREB-bp-like, interlocking domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P61
Unit cell:
a: 81.694Å b: 81.694Å c: 242.096Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.214 0.226
Expression system: Escherichia coli