PDBe 1zn7

X-ray diffraction
1.83Å resolution

Human Adenine Phosphoribosyltransferase Complexed with PRPP, ADE and R5P

Released:

Function and Biology Details

Reaction catalysed:
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenine phosphoribosyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 180 amino acids
Theoretical weight: 19.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P07741 (Residues: 1-180; Coverage: 100%)
Gene name: APRT
Sequence domains: Phosphoribosyl transferase domain
Structure domains: Rossmann fold

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P1
Unit cell:
a: 47.019Å b: 47.267Å c: 47.522Å
α: 76.59° β: 69.26° γ: 61.89°
R-values:
R R work R free
0.148 0.146 0.19
Expression system: Escherichia coli BL21(DE3)