PDBe 1zmp

X-ray diffraction
1.65Å resolution

Crystal structure of human defensin-5

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structures of human alpha-defensins HNP4, HD5, and HD6.
Protein Sci. 15 2749-60 (2006)
PMID: 17088326

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
monomeric
homo octamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HD5(63-94) Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 32 amino acids
Theoretical weight: 3.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01523 (Residues: 63-94; Coverage: 43%)
Gene names: DEF5, DEFA5
Sequence domains: Mammalian defensin

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P6522
Unit cell:
a: 49.375Å b: 49.375Å c: 255.185Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.2 0.198 0.24
Expression system: Escherichia coli