PDBe 1zmd

X-ray diffraction
2.08Å resolution

Crystal Structure of Human dihydrolipoamide dehydrogenase complexed to NADH


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Dihydrolipoyl dehydrogenase, mitochondrial Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 474 amino acids
Theoretical weight: 50.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P09622 (Residues: 36-509; Coverage: 93%)
Gene names: DLD, GCSL, LAD, PHE3
Sequence domains:
Structure domains:

Ligands and Environments

Cofactor: Ligand FAD 8 x FAD

Cofactor: Ligand NAI 8 x NAI
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 175.871Å b: 210.914Å c: 127.096Å
α: 90° β: 90° γ: 90°
R R work R free
0.221 0.221 0.249
Expression system: Escherichia coli