PDBe 1zmc

X-ray diffraction
2.53Å resolution

Crystal Structure of Human dihydrolipoamide dehydrogenase complexed to NAD+

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydrolipoyl dehydrogenase, mitochondrial Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 474 amino acids
Theoretical weight: 50.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09622 (Residues: 36-509; Coverage: 93%)
Gene names: DLD, GCSL, LAD, PHE3
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAD 8 x NAD

Cofactor: Ligand FAD 8 x FAD
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 176.124Å b: 210.763Å c: 126.903Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.211 0.267
Expression system: Escherichia coli