PDBe 1z9e

Solution NMR

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

Released:
Source organism: Homo sapiens
Primary publication:
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75.
Nat. Struct. Mol. Biol. 12 526-32 (2005)
PMID: 15895093

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PC4 and SFRS1-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O75475 (Residues: 346-471; Coverage: 24%)
Gene names: DFS70, LEDGF, PSIP1, PSIP2
Sequence domains: Lens epithelium-derived growth factor (LEDGF)
Structure domains: Conserved domain common to transcription factors TFIIS, elongin A, CRSP70

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21