PDBe 1ymm

X-ray diffraction
3.5Å resolution

TCR/HLA-DR2b/MBP-peptide complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Myelin basic protein Chain: C
Molecule details ›
Chain: C
Length: 23 amino acids
Theoretical weight: 2.29 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02686 (Residues: 217-242; Coverage: 8%)
  • Best match: P02686-4 (Residues: 110-124)
Gene name: MBP
T-cell receptor beta-1 chain C region Chain: E
Molecule details ›
Chain: E
Length: 249 amino acids
Theoretical weight: 27.93 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01850 (Residues: 1-131; Coverage: 74%)
Gene name: TRBC1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
T-cell receptor alpha chain C region Chain: D
Molecule details ›
Chain: D
Length: 207 amino acids
Theoretical weight: 22.98 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01848 (Residues: 2-96; Coverage: 67%)
Gene names: TCRA, TRAC
Sequence domains: Domain of unknown function (DUF1968)
Structure domains: Immunoglobulins
HLA class II histocompatibility antigen, DRB1-15 beta chain Chain: B
Molecule details ›
Chain: B
Length: 198 amino acids
Theoretical weight: 22.99 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01911 (Residues: 30-227; Coverage: 84%)
Gene names: HLA-DRB1, HLA-DRB2
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DR alpha chain Chain: A
Molecule details ›
Chain: A
Length: 191 amino acids
Theoretical weight: 22.11 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P01903 (Residues: 26-216; Coverage: 83%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: F222
Unit cell:
a: 137.34Å b: 212.62Å c: 278.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.276 0.274 0.318
Expression systems:
  • Not provided
  • Drosophila melanogaster