PDBe 1xur

X-ray diffraction
1.85Å resolution

Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor

Released:
Source organism: Homo sapiens
Primary publication:
Making a new turn in matrix metalloprotease inhibition.
Chem. Biol. 12 143-4 (2005)
PMID: 15734640

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Collagenase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 171 amino acids
Theoretical weight: 19.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45452 (Residues: 104-274; Coverage: 38%)
Gene name: MMP13
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2
Unit cell:
a: 134.508Å b: 36.486Å c: 95.586Å
α: 90° β: 130.523° γ: 90°
R-values:
R R work R free
0.167 0.167 0.206
Expression system: Escherichia coli