PDBe 1xtq

X-ray diffraction
2Å resolution

Structure of small GTPase human Rheb in complex with GDP

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis for the unique biological function of small GTPase RHEB.
J. Biol. Chem. 280 17093-100 (2005)
PMID: 15728574

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTP-binding protein Rheb Chain: A
Molecule details ›
Chain: A
Length: 177 amino acids
Theoretical weight: 20.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15382 (Residues: 1-169; Coverage: 92%)
Gene names: RHEB, RHEB2
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 44.48Å b: 52.26Å c: 70.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.219 0.257
Expression system: Escherichia coli BL21(DE3)