PDBe 1xmn

X-ray diffraction
1.85Å resolution

Crystal structure of thrombin bound to heparin

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of thrombin bound to heparin.
J. Biol. Chem. 280 2745-9 (2005)
PMID: 15548541

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero octamer (preferred)
hetero dimer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thrombin light chain Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Thrombin heavy chain Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P21
Unit cell:
a: 80.907Å b: 80.841Å c: 114.144Å
α: 90° β: 101.05° γ: 90°
R-values:
R R work R free
0.209 0.209 0.234