PDBe 1xm1

X-ray diffraction
2.3Å resolution

Nonbasic Thrombin Inhibitor Complex

Released:
Source organisms:
Entry authors: Friedrich R, Bode W, Schwienhorst A

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thrombin heavy chain Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 33.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 328-622; Coverage: 49%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Hirudin-2 Chain: H
Molecule details ›
Chain: H
Length: 10 amino acids
Theoretical weight: 1.36 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
  • Canonical: P28504 (Residues: 55-64; Coverage: 15%)

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2
Unit cell:
a: 70.46Å b: 70.93Å c: 72.65Å
α: 90° β: 100.38° γ: 90°
R-values:
R R work R free
0.201 0.201 0.266
Expression system: Not provided