PDBe 1xkb

X-ray diffraction
2.4Å resolution

FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis for chemical inhibition of human blood coagulation factor Xa.
Proc. Natl. Acad. Sci. U.S.A. 95 6630-5 (1998)
PMID: 9618463

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Factor X light chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 95 amino acids
Theoretical weight: 10.39 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 85-179; Coverage: 21%)
Gene name: F10
Sequence domains:
Structure domains: Laminin
Activated factor Xa heavy chain Chains: C, D
Molecule details ›
Chains: C, D
Length: 235 amino acids
Theoretical weight: 26.6 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 235-469; Coverage: 51%)
Gene name: F10
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P21
Unit cell:
a: 58.27Å b: 105.22Å c: 63.24Å
α: 90° β: 103.4° γ: 90°
R-values:
R R work R free
0.206 0.206 0.294