PDBe 1xdl

X-ray diffraction
3Å resolution

Structure of human aldolase B associated with hereditary fructose intolerance (A149P), at 277K

Released:

Function and Biology Details

Reaction catalysed:
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fructose-bisphosphate aldolase B Chains: A, B, C, D, W, X, Y, Z
Molecule details ›
Chains: A, B, C, D, W, X, Y, Z
Length: 365 amino acids
Theoretical weight: 39.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05062 (Residues: 2-364; Coverage: 100%)
Gene names: ALDB, ALDOB
Sequence domains: Fructose-bisphosphate aldolase class-I
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21212
Unit cell:
a: 153.483Å b: 153.513Å c: 186.479Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.324 0.304 0.349
Expression system: Escherichia coli