PDBe 1wwa

X-ray diffraction
2.5Å resolution

NGF BINDING DOMAIN OF HUMAN TRKA RECEPTOR

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
High affinity nerve growth factor receptor Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 109 amino acids
Theoretical weight: 12.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04629 (Residues: 278-386; Coverage: 14%)
Gene names: MTC, NTRK1, TRK, TRKA
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P41212
Unit cell:
a: 106.42Å b: 106.42Å c: 75.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.207 0.258
Expression system: Escherichia coli