PDBe 1w7k

X-ray diffraction
2.1Å resolution

E.coli FolC in complex with ADP, without folate substrate


Function and Biology Details

Reactions catalysed:
ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1). 
ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8- dihydropteroylglutamate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Dihydrofolate synthase/folylpolyglutamate synthase Chain: A
Molecule details ›
Chain: A
Length: 422 amino acids
Theoretical weight: 45.5 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
  • Canonical: P08192 (Residues: 1-422; Coverage: 100%)
Gene names: JW2312, b2315, dedC, folC
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: P212121
Unit cell:
a: 66.112Å b: 81.602Å c: 93.673Å
α: 90° β: 90° γ: 90°
R R work R free
0.177 0.177 0.231
Expression system: Escherichia coli