PDBe 1w72

X-ray diffraction
2.15Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
HYB3 HEAVY CHAIN Chains: H, I
Molecule details ›
Chains: H, I
Length: 223 amino acids
Theoretical weight: 23.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
HYB3 LIGHT CHAIN Chains: L, M
Molecule details ›
Chains: L, M
Length: 210 amino acids
Theoretical weight: 22.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Melanoma-associated antigen 1 Chains: C, F
Molecule details ›
Chains: C, F
Length: 9 amino acids
Theoretical weight: 977 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P43355 (Residues: 161-169; Coverage: 3%)
Gene names: MAGE1, MAGE1A, MAGEA1
HLA class I histocompatibility antigen, A-1 alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 274 amino acids
Theoretical weight: 31.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30443 (Residues: 25-298; Coverage: 80%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 125.359Å b: 50.05Å c: 136.705Å
α: 90° β: 109.85° γ: 90°
R-values:
R R work R free
0.186 0.182 0.248
Expression systems:
  • Escherichia coli
  • Not provided