PDBe 1w6m

X-ray diffraction
2.3Å resolution

X-RAY CRYSTAL STRUCTURE OF C2S HUMAN GALECTIN-1 COMPLEXED WITH GALACTOSE

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Galectin-1 Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 14.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW P09382 (Residues: 2-135; Coverage: 99%)
Gene name: LGALS1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls
Galectin-1 Chain: B
Molecule details ›
Chain: B
Length: 134 amino acids
Theoretical weight: 14.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW P09382 (Residues: 2-135; Coverage: 99%)
Gene name: LGALS1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: P212121
Unit cell:
a: 36.776Å b: 88.898Å c: 93.913Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.201 0.241
Expression system: Escherichia coli