PDBe 1w6k

X-ray diffraction
2.1Å resolution

Structure of human OSC in complex with Lanosterol


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Lanosterol synthase Chain: A
Molecule details ›
Chain: A
Length: 732 amino acids
Theoretical weight: 83.39 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
  • Canonical: P48449 (Residues: 1-732; Coverage: 100%)
Gene names: LSS, OSC
Sequence domains: Prenyltransferase and squalene oxidase repeat
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2221
Unit cell:
a: 189.57Å b: 201.472Å c: 62.006Å
α: 90° β: 90° γ: 90°
R R work R free
0.147 0.147 0.188
Expression system: Komagataella pastoris