PDBe 1w1i

X-ray diffraction
3.03Å resolution

Crystal structure of dipeptidyl peptidase IV (DPPIV or CD26) in complex with adenosine deaminase

Released:

Function and Biology Details

Reactions catalysed:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Adenosine + H(2)O = inosine + NH(3)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dipeptidyl peptidase 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 728 amino acids
Theoretical weight: 84.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P27487 (Residues: 39-766; Coverage: 95%)
Gene names: ADCP2, CD26, DPP4
Sequence domains:
Structure domains:
Adenosine deaminase Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 357 amino acids
Theoretical weight: 40.46 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P56658 (Residues: 1-357; Coverage: 98%)
Gene name: ADA
Sequence domains: Adenosine/AMP deaminase
Structure domains: Metal-dependent hydrolases

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2
Unit cell:
a: 158.065Å b: 168.504Å c: 236.842Å
α: 90° β: 100.54° γ: 90°
R-values:
R R work R free
0.224 0.224 0.257
Expression system: Spodoptera frugiperda