PDBe 1v4t

X-ray diffraction
3.4Å resolution

Crystal structure of human glucokinase

Released:

Function and Biology Details

Reaction catalysed:
ATP + D-glucose = ADP + D-glucose 6-phosphate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucokinase Chain: A
Molecule details ›
Chain: A
Length: 451 amino acids
Theoretical weight: 50.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35557 (Residues: 16-465; Coverage: 97%)
Gene name: GCK
Sequence domains: Hexokinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32B2
Spacegroup: P6522
Unit cell:
a: 103.18Å b: 103.18Å c: 281.02Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.256 0.237 0.307
Expression system: Escherichia coli