PDBe 1uym

X-ray diffraction
2.45Å resolution

Human Hsp90-beta with PU3 (9-Butyl-8(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein HSP 90-beta Chain: A
Molecule details ›
Chain: A
Length: 220 amino acids
Theoretical weight: 24.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: NEW P08238 (Residues: 2-221; Coverage: 30%)
Gene names: HSP90AB1, HSP90B, HSPC2, HSPCB
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Histidine kinase-like ATPase, C-terminal domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: I222
Unit cell:
a: 66.861Å b: 90.707Å c: 96.289Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.235 0.294
Expression system: Escherichia coli BL21(DE3)