PDBe 1us0

X-ray diffraction
0.66Å resolution

Human Aldose Reductase in complex with NADP+ and the inhibitor IDD594 at 0.66 Angstrom

Released:

Function and Biology Details

Reaction catalysed:
Alditol + NAD(P)(+) = aldose + NAD(P)H
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aldose reductase Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 35.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15121 (Residues: 1-316; Coverage: 100%)
Gene names: AKR1B1, ALDR1
Sequence domains: Aldo/keto reductase family
Structure domains: NADP-dependent oxidoreductase domain

Ligands and Environments


Cofactor: Ligand NDP 1 x NDP
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 49.28Å b: 66.59Å c: 47.26Å
α: 90° β: 92.4° γ: 90°
R-values:
R R work R free
0.094 not available 0.103
Expression system: Escherichia coli