PDBe 1uj2

X-ray diffraction
1.8Å resolution

Crystal structure of human uridine-cytidine kinase 2 complexed with products, CMP and ADP


Function and Biology Details

Reaction catalysed:
ATP + uridine = ADP + UMP
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Uridine-cytidine kinase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 252 amino acids
Theoretical weight: 28.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: Q9BZX2 (Residues: 1-250; Coverage: 96%)
Gene names: UCK2, UMPK
Sequence domains: Phosphoribulokinase / Uridine kinase family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2
Unit cell:
a: 89.022Å b: 109.714Å c: 64.845Å
α: 90° β: 95.32° γ: 90°
R R work R free
0.193 0.19 0.217
Expression system: Escherichia coli BL21