PDBe 1ttr

X-ray diffraction
1.9Å resolution

TRANSTHYRETIN-V/122/I CARDIOMYOPATHIC MUTANT

Released:
Source organism: Homo sapiens
Primary publication:
Structure of the Val122Ile variant transthyretin - a cardiomyopathic mutant.
Acta Crystallogr. D Biol. Crystallogr. 52 966-72 (1996)
PMID: 15299606

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P21212
Unit cell:
a: 43.23Å b: 85.64Å c: 65.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.158 0.158 not available
Expression system: Escherichia coli