PDBe 1tnr

X-ray diffraction
2.85Å resolution

CRYSTAL STRUCTURE OF THE SOLUBLE HUMAN 55 KD TNF RECEPTOR-HUMAN TNF-BETA COMPLEX: IMPLICATIONS FOR TNF RECEPTOR ACTIVATION

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Lymphotoxin-alpha Chain: A
Molecule details ›
Chain: A
Length: 144 amino acids
Theoretical weight: 15.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01374 (Residues: 62-205; Coverage: 84%)
Gene names: LTA, TNFB, TNFSF1
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls
Tumor necrosis factor-binding protein 1 Chain: R
Molecule details ›
Chain: R
Length: 139 amino acids
Theoretical weight: 15.77 KDa
Source organism: Homo sapiens
Expression system: SF9 cells
UniProt:
  • Canonical: P19438 (Residues: 44-182; Coverage: 33%)
Gene names: TNFAR, TNFR1, TNFRSF1A
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: I23
Unit cell:
a: 145.64Å b: 145.64Å c: 145.64Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.16 0.16 not available
Expression systems:
  • Escherichia coli
  • SF9 cells